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A struggling club will travel across the country to take on a team that is on fire. The San Francisco 49ers and their fans are learning Chip Kelly is not the answer, as they suffered their fourth straight loss a week ago, at the hands of the Arizona Cardinals on Thursday Night Football. Meanwhile, the Bills won their third straight, after coming across the country to defeat the Los Angeles Rams, who had been on a roll of their own before last week.

The 49ers will be making a change this week. After five weeks of suffering through Blaine Gabbert under center, the Niners will turn to Colin Kaepernick. Unfortunately for the 49ers, that is probably not going to change much, as the rest of the team is pretty terrible. If it was not for the Browns, I would say San Fran would be the favorites to land the number one pick in the 2017 NFL Draft. And this week they go East after loosing two straight at home in Levi Stadium. Every time I have put some faith in the 49ers with about seven or so points, they let me down. So I have learned my lesson, and I will not be trusting the Niners again.

The Bills are one of the biggest surprises on the young season. Three weeks ago they made the Cardinals look like the Browns, and picked off Carson Palmer almost every time he dropped back to throw. Then the following week, Rex Ryan’s club chocked the world, going into New England and shutting out the Patriots. Then last week, not only did they go into Los Angeles and beat a hot Rams team, but they made it look easy, 30-19. So I am sure a letdown game is on the horizon for Buffalo. So it could very well be this week, but I am going to say it waits one more week. Being home against one of the worst teams in the NFL, I can’t not pick the Bills in this one.

For all week six NFL Spreads and Over/Under’s, check out our NFL week 6 Betting Odds master-sheet here.

Line: Bills -7.5, O/U: 44

Pick: Bills and the under

Result: Buf 45 – SF 16, Bills and the over