In the ever-advancing field of structural biology, Shuimu BioSciences stands at the forefront. Founded in 2017 at Tsinghua University, Shuimu has grown into Asia’s premier commercial platform for cryo-electron microscopy (cryo-EM) structure determination. With cutting-edge infrastructure, a highly specialized team, and end-to-end biological solutions, Shuimu delivers unmatched precision and speed for life science researchers and pharmaceutical developers worldwide.
Why Cryo-EM Is Changing the Game
Cryo-EM enables the visualization of biomacromolecules in near-native conditions at atomic resolutions. This breakthrough technology requires only small sample volumes and captures diverse conformations, making it a superior alternative to traditional X-ray crystallography, especially for membrane proteins, viruses, and antibody-antigen complexes.
Comprehensive “Gene-to-Structure” Workflow
Shuimu BioSciences offers a seamless, one-stop workflow that includes:
- Protein expression in E. coli, insect, mammalian, and cell-free systems
- Advanced purification techniques: affinity, ion exchange, gel filtration, and RP-HPLC
- Single Particle Analysis (SPA) and MicroED for high-resolution 3D structural determination
- Functional assays: SPR, BLI, ELISA
- Custom antibody discovery and validation pipelines
This integrated approach reduces variability, improves reproducibility, and accelerates drug discovery workflows.
Industry-Leading Cryo-EM Capabilities
With two 300 kV instruments in Beijing and six in Hangzhou, Shuimu operates the world’s largest commercial cryo-EM platform. These high-throughput facilities support 24/7 data collection, aided by Shuimu’s proprietary AI-driven SMART software for enhanced image processing and reconstruction.
Shuimu also pioneers sample preparation using its GraFuture™ graphene grids, which minimize background noise and resolve challenges related to small or low-concentration proteins—making them ideal for challenging targets.
Applications Across Drug and Vaccine Development
- Drug Discovery & Antibody Design
By revealing how small molecules and antibodies bind to target proteins, cryo-EM helps researchers understand mechanisms of action, design more potent drugs, and reduce development time. - Vaccine Research and Quality Control
Shuimu supports structure-guided vaccine design for pathogens such as SARS-CoV-2 and influenza. Cryo-EM is also employed to assess particle morphology and antigen integrity during production, ensuring quality and efficacy. - Membrane Proteins and Complex Targets
With deep expertise in GPCRs, ion channels, and transporters, Shuimu is uniquely positioned to tackle some of the most difficult structural targets in biomedicine.
Global Expertise and Proven Track Record
Shuimu’s elite team includes PhD-level scientists from top academic institutions. To date, the company has successfully completed over 400 cryo-EM projects and resolved more than 150 high-resolution structures, with resolutions reaching as fine as 1.4 Å.
The company’s work is regularly featured in leading journals such as Nature, Cell, and Science Advances. Notable case studies include structural determinations of GPR75, TRPV4, and the SARS-CoV-2 spike protein complex.
Full-Service Offerings at a Glance
- Single Particle Analysis (SPA): high-resolution 3D macromolecular reconstruction
- Protein Expression & Purification: customizable expression systems and scalable purification
- MicroED Solutions: sub-angstrom structural resolution of microcrystals
- Crystallography Services: one-stop antigen-antibody and complex structure solutions
- Antibody Discovery: from screening to affinity testing
- Biochemical Assays: SPR, BLI, ELISA, and more
Partner with Shuimu BioSciences Today
Whether you’re a research institution or a pharmaceutical company, Shuimu BioSciences offers everything needed to turn biological complexity into structural clarity. From data acquisition to structure interpretation, Shuimu is a trusted partner in accelerating scientific breakthroughs.
Explore their full range of services at Shuimu BioSciences — your gateway to precision structural biology.