Fisetin supplements have become a popular choice for wellness enthusiasts searching for nootropics. There’s an abundance of research crediting these products for their mental and neurological benefits.
As with most dietary supplements, the best way to unlock fisetin’s perceived therapeutic benefits is to use premium-quality products that are carefully formulated with pure fisetin and other beneficial compounds. It’s also prudent to shun products containing synthetic additives associated with chronic health problems.
But even before shopping for fisetin supplements, it would help to understand what this compound is and how it might improve your brain health. That’s precisely what this article shall cover.
Introducing Fisetin
Fisetin is a plant flavonol that exists naturally as a yellow coloring agent in several trees and shrubs, particularly those in the Fabaceae family, like acacias and the honey locust tree. It’s also abundant in many fruits and vegetables, including apples, strawberries, grapes, persimmons, cucumbers, and onions.
Fisetin belongs to the flavonoid group of polyphenols, a group of biochemicals that contain powerful healing properties. The flavonol was first isolated in 1833. Since then, there has been mounting scientific evidence pointing to its remarkable therapeutic potential. That explains the growing interest in fisetin-infused supplements.
Investing in the best fisetin supplement can provide a host of health benefits, including supporting mental and neurological development. More on that in the next section.
5 Ways Fisetin Supplements May Support Your Brain Health
Fisetin and Free Radicals
Free radicals are unstable molecules containing at least one unpaired electron in their outer shells. These molecules are a result of various physiological processes.
Free radicals are typically neutralized by antioxidants, which give up some of their electrons to restore a proton-electron balance in body cells.
If allowed to accumulate unabated, free radicals can trigger a phenomenon called oxidative stress. Oxidative stress is characterized by damage to DNA, RNA, and essential proteins, eventually leading to chronic diseases and even death.
Fisetin is a powerful antioxidant known to counter the adverse effects of free radicals in various body organs, including the brain. The compound is particularly effective against reactive oxygen species (ROS), one of the most widely studied free radicals. Supplementing with fisetin can go a long way in lowering the incidences of degenerative brain diseases like Alzheimer’s.
Fisetin and Senescent Cells
Cellular senescence is a phenomenon in which cells stop dividing.
Note that cell division plays a critical role in living organisms. It notably supports cell growth, repair, and regeneration.
Not all senescent cells (cells that have ceased reproducing) are harmful. However, most have been linked to high risks of disease and a decrease in the quality of life. They’re especially notorious for causing brain tumors and symptoms of cerebral aging, such as poor memory and a short attention span.
Fisetin is considered a senotherapeutic, which means it can induce the apoptosis (cell death) of senescent cells. There’s solid evidence that the compound may reduce the amount of senescent cells in the body, a mechanism that might induce cell regeneration.
Fisetin and Brain Aging
All body organs undergo a gradual decline in performance with age. The brain ages at a remarkably fast rate due to its central role as a regulator of all biological processes.
Some research indicates that consuming fisetin supplements might help to extend lifespan and protect against brain aging.
Fisetin prevents age-related decline in brain performance by reversing oxidative stress in cerebral cells and tissues. The compound also possesses some anti-inflammatory properties and may cushion the brain from inflammatory conditions like cerebral tumors.
Fisetin’s efficacy against the early onset of brain aging symptoms may help to improve various aspects of cognitive and behavioral performance.
Fisetin and Poor GSH Signaling
Glutathione (GSH) is a water-soluble tripeptide comprising the amino acids glutamine, glycine, and cysteine. The peptide is produced by the liver. It involves several functions, such as tissue building and repair, enzyme and protein synthesis, and immune system boosting.
Fisetin regulates glutathione by activating two major transcription factors that modulate GSH levels, namely ATF4 and Nrf2.
ATF4 has proven to be the more effective GSH regulator under basal circumstances. However, the compound works synergistically with Nrf2 to increase GSH levels during periods of oxidative stress. This can prevent free radicals from taking a toll on your cerebral health.
GSH is more reliable at countering the adverse effects of free radicals than most endogenous antioxidants. That’s due to its -thiol group, which functions as a reducing agent, enhancing the peptide’s access to target tissues.
Fisetin and Low Dopamine Levels
Fisetin has also been shown to increase dopamine levels, lending further credence to its nootropic properties.
Dopamine is a neurotransmitter noted for its role in regulating mental health. The chemical acts on distinct brain regions associated with pleasure, optimism, and satisfaction. It also controls mood, memory, learning, concentration, sleep, and movement.
Low dopamine levels in the bloodstream are characterized by low self-drive and fatigue. Other symptoms include reduced libido, depression, hopelessness, mood swings, and inability to concentrate.
Fortunately, fisetin increases both dopamine production and signaling. It consequently activates “feel-good” vibes while allowing you to tap into your creative juices.
Wrap Up
Despite their undeniable nootropic properties, the efficacy of fisetin supplements largely depends on their secondary ingredients. It’s also prudent to consume these products moderately, as an overdose might trigger adverse gastrointestinal reactions.
Besides, always consult a licensed physician or dietician before using fisetin supplements.